Preprints

• Zhang L, Omarov M, Xu L, Das B, Luo H, Hauch SM, Petrera A, Yu Z, Goonewardena SN, Zeggini E, Peters A, Dichgans M, Murthy VL, Thorand B, Georgakis MK. Proteomic Signatures as Biomarkers of Atherosclerosis Burden. ResearchSquare. 2025. doi: https://doi.org/10.21203/rs.3.rs-6837440/v1

• Živković L, Batool R, Louma J,  Alabarse PVG,  Li Y,  Zhang L, Mayrhofer S,  Ray A,  Antabi MA,  Zangas P, Mattar J,  Kopczak A, Schindler A, Reidler P,  Asare Y,  Tiedt S,  Kellert L,  Rantner B,  Dichgans M,  Tsilimiparis N,  Georgakis MK. Multi-omic profiling of atherosclerosis: protocol and pilot data for the AtherOMICS biobank. MedRxiv. 2025.06.17.25329773; doi: https://doi.org/10.1101/2025.06.17.25329773

• Zhang L, Antabi MA, Mattar J, El Bounkari O, Fang R, Waegemann K, Bode FJ, Stösser S, Hermann P, Liman TG, Nolte CH, Ikenberg B, Bernkopf K, Glanz W, Janowitz D, Spottke A, Görtler MW, Wunderlich S, Zerr I, Petzold GC, Endres M, Bernhagen J, Dichgans M, Georgakis MK. Circulating cytokine levels and 5-year vascular recurrence after stroke: a multicenter prospective cohort study. MedRxiv. 2025;2025.01.12.25320408. doi: https://doi.org/10.1101/2025.01.12.25320408

• Omarov M, Zhang L, Doroodgar Jorshery S, … Georgakis MK. Deep Learning-Based Detection of Carotid Plaques Informs Cardiovascular Risk Prediction and Reveals Genetic Drivers of Atherosclerosis. MedRxiv. 2024.10.17.24315675. doi: 10.1101/2024.10.17.24315675.

• Tchuisseu-Kwangoua LA, Omarov M, Shatunov A, Markus HS, Kamtchum-Tatuene J, Georgakis MK. Genetic downregulation of interleukin-6 signaling and arteriolosclerotic cerebral small vessel disease: a drug target Mendelian randomization analysis. MedRxiv. 2024;2024.12.13.24318994. doi: https://doi.org/10.1101/2024.12.13.24318994

2025

• Ray A, Alabarse P, Malik R, Sargurupremraj M, Bernhagen J, Dichgans M, Baumeister SE, Georgakis MK. Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease. Am J Hum Genet. 2025 Jun 17:S0002-9297(25)00232-0. doi: 10.1016/j.ajhg.2025.06.001. Online ahead of print.

• Bragazzi NL, Zhang L, Omarov M, Georgakis MK. Genetic Risk Scores in Stroke Research and Care. Stroke. 2025 May 21. doi: 10.1161/STROKEAHA.125.050961.

• Georgakis MK, Malik R, Hasbani NR, et al. Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. Genome Med. 2025 Mar 21;17(1):27. doi: 10.1186/s13073-025-01456-2.

• Konieczny M, Omarov M, Malik R, Richardson TG, Baumeister SE, Bernhagen J, Dichgans M, Georgakis MK. The Genomic Architecture of Circulating Cytokine Levels Points to Drug Targets for Immune-Related Diseases. Commun Biol. 2025 Jan 10;8(1):34. doi: 10.1038/s42003-025-07453

2024

• Stroke genetics informs drug discovery and risk prediction across ancestries. A Mishra, R Malik, T Hachiya, T Jürgenson, S Namba, DC Posner. Nature 611 (7934), 115-123.

• Stroke genetics informs drug discovery and risk prediction across ancestries. A Mishra, R Malik, T Hachiya, T Jürgenson, S Namba, DC Posner. Nature 611 (7934), 115-123.

• Stroke genetics informs drug discovery and risk prediction across ancestries. A Mishra, R Malik, T Hachiya, T Jürgenson, S Namba, DC Posner. Nature 611 (7934), 115-123.

2024

• Fang R, Duering M, Bode FJ, …, Georgakis MK*, Dichgans M*. Risk factors and clinical significance of post-stroke incident ischemic lesions. Alzheimers Dement. 2024 Oct 17. Online ahead of print (*equally contributed).

• Prapiadou S, Zivkovic L, Thorand B, …, Georgakis MK. Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis. Circulation. Feb 27;149(9):669-683.

• Myserlis EP, Ray A, Anderson CD, Georgakis MK. Genetically proxied IL-6 signaling and risk of Alzheimer's disease and lobar intracerebral hemorrhage: A drug target Mendelian randomization study. Alzheimers Dement (N Y). 2024 Aug 27;10(3):e70000.

• Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, …, Liesz A. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature. 2024 Sep;633(8029):433-441.

• Filler J, Georgakis MK, Dichgans M. Risk factors for cognitive impairment and dementia after stroke: a systematic review and meta-analysis. Lancet Healthy Longev. 2024 Jan;5(1):e31-e44.

2023

• Myserlis EP, Anderson CD, Georgakis MK. Genetically Proxied CRP (C-Reactive Protein) Levels and Lobar Intracerebral Hemorrhage Risk. Stroke. 2023 Apr;54(4):e130-e132.

• Myserlis EP*, Georgakis MK*, Demel SL, et al. A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage. Stroke. 2023 Apr;54(4):973-982 (*equally contributed).

• Mayerhofer E, Parodi L, Prapiadou S, Malik R, Rosand J, Georgakis MK*, Anderson CD*. Genetic Risk Score Improves Risk Stratification for Anticoagulation-Related Intracerebral Hemorrhage. Stroke. 2023 Mar;54(3):791-799 (*equally contributed).

• Georgakis MK, Rong F, Düring M, et al. Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study. Alzheimers Dement. 2023 Apr;19(4):1152-1163.

2022

• Georgakis MK, Bernhagen J, Heitman L, Weber C, Dichgans M. Targeting the CCL2-CCR2 Axis for Atheroprotection: Triangulation of Evidence and Steps Towards Clinical Translation. Eur Heart J. 2022 May 14;43(19):1799-1808.

• Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, et al. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022 Nov;611(7934):115-123

• Mayerhofer E, Malik R, Parodi L, …, Anderson CD, Georgakis MK. Genetically predicted on-statin LDL response is associated with higher intracerebral haemorrhage risk. Brain. 2022 May 22;awac186.

• Georgakis MK, Malik R, Richardson TG, et al. Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups. BMC Med. 2022 Aug 11;20(1):245.

• Georgakis MK, Parodi L, Frerich S, et al. Genetic architecture of stroke of undetermined source: overlap with known stroke etiologies and associations with modifiable risk factors. Ann Neurol. 2022 May;91(5):640-651.

• Živković L, Asare Y, Bernhagen J, Dichgans M, Georgakis MK. Pharmacological Targeting of the CCL2/CCR2 Axis for Atheroprotection: A Meta-Analysis of Preclinical Studies. Arterioscler Thromb Vasc Biol. 2022 May;42(5):e131-e144.

• Papadopoulos A, Palaiopanos K, Björkbacka H, …, Georgakis MK. Circulating interleukin-6 levels and incident ischemic stroke: a systematic review and meta-analysis of prospective studies. Neurology. 2022 Mar 8;98(10):e1002-e1012.

• Georgakis MK, Malik R, Burgess S, Dichgans M. Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density-Lipoprotein Cholesterol Lowering on Cardiovascular Risk: A 2X2 Factorial Mendelian Randomization Analysis. J Am Hear Assoc. 2022 Jan 4;11(1):e023277.

2021

• Georgakis MK, van der Laan S., Asare Y, et al. Monocyte-chemoattractant protein-1 Levels in Human Atherosclerosis Associate with Plaque Vulnerability. Arterioscler Thromb Vasc Biol. 2021;41(6):2038-2048.

• Georgakis MK, Gill D. Mendelian Randomization Studies in Stroke: Exploration of Risk Factors and Drug Targets With Human Genetic Data. Stroke. 2021. Aug;52(9):2992-3003.

• Georgakis MK, de Lemos JA, Ayers C, et al. Circulating monocyte chemoattractant protein-1 levels are associated with cardiovascular mortality: a meta-analysis of population-based studies.  JAMA Cardiol. 2021;6(5):587-592.

• Georgakis MK, Malik R, Li X, et al. Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association study. Circulation. 2021;143(11):1177-1180.

• Georgakis MK, Harshfield E, Malik R, …, Dichgans M. Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study. Neurology. 2021;96(13):e1732-e1742.

2020

• Georgakis MK, Malik R, Gill D, …, Dichgans M. Interleukin-6 signaling effects on ischemic stroke and other cardiovascular outcomes: a Mendelian Randomization study.   Circ Genom Precis Med. 2020;13(3):e002872.

• Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M. Genetically determined blood lipids and cerebral small vessel disease: role of HDL cholesterol. Brain. 2020;143(2):597-610.

• Papadopoulos A, Palaiopanos K, Protogerou AP, Paraskeuas G, Tsivgoulis G, Georgakis MK.  Left ventricular hypertrophy and cerebral small vessel disease: a systematic review and meta-analysis.  J Stroke. 2020;22(2):206-224.

• Georgakis MK, Gill D, Malik R, Protogerou AD, Webb WJS, Dichgans M. Genetically predicted blood pressure across the lifespan: differential effects of mean and pulse pressure on stroke risk. Hypertension. 2020 Sep;76(3):953-961.

• Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M. Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke: a Mendelian Randomization Study. Neurology. 2020 Jul 28;95(4):e353-e361.

Pre-2020

• Georgakis MK, Malik R, Björkbacka H, …, Dichgans M. Circulating monocyte chemoattractant protein-1 and risk of stroke: a meta-analysis of population-based studies involving 17,180 individuals. Circ Res 2019;125:773-782.

• Georgakis MK, Gill D, Rannikmäe K, …, Dichgans M.  Genetically Determined Levels of Circulating Cytokines and Risk of Stroke: Role of Monocyte Chemoattractant Protein-1. Circulation 2019;139(2):256-268.

• Georgakis MK, Duering M, Wardlaw JM, Dichgans M.  WMH and long-term outcomes in ischemic stroke: a systematic review and meta-analysis.  Neurology. 2019;92(12):e1298-e1308.

• Georgakis MK, Chatzopoulou D, Tsivgoulis G, Petridou ET. Albuminuria and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis. J Am Geriatr Soc. 2018;66(3):509-517.

• Georgakis MK, Dimitriou NG, Karalexi MA, …, Petridou ET.  Albuminuria in association with dementia and cognitive function: a systematic review and meta-analysis. J Am Ger Soc.  2017;65(6):1190-1198.

• Georgakis MK, Thomopoulos TP, Diamantaras AA, Kalogirou EI, Skalkidou A, Daskalopoulou SS, Petridou ET. Age at menopause and duration of reproductive period in association with depression in postmenopausal women: a systematic review and meta-analysis. JAMA Psychiatry. 2016;73(2):139-149.